Introduction

The Magnetic Resonance Molecular Imaging Team (MRMIT) observes the functions of cells and molecules in living organs and tissues using high field magnetic resonance imaging (MRI). Our ultimate goal is to contribute to the detection and treatment of disease and the development of drugs. We are currently improving new and smart contrast agents using our 7 Tesla MRI system for accurate and quantitative imaging of molecular functions. We also develop RF probes and disease experimental models in order to assist with the early diagnosis of diseases and to evaluate the effectiveness of treatment.

Research Introduction

1) Development of novel probes and techniques for imaging of cellular and molecular function We are developing nanobioprobes for specific and highly sensitive detection of molecular/cellular targets and functions in living cells, tissues, and organs. We have developed a method to image the opening of the Ca-channel of the neuron membrane using a Manganese contrast agent. The agent can visualize the laminar structures of the cerebral cortex and fiber tracks.

2) Research for cerebral blood flow and metabolism Accurate diagnosis often requires quantitative measurement of CBF and metabolism. Accurate CBF measurements will also help to observe brain network and the function. Thus, the development of high-resolution and high-speed methods for measuring CBF and metabolism are indispensable for neuroscience research.

3) Improvement of high field MRI system A 7-Tesla/400mm MRI and strong gradient coils are available for mouse, rat, marmoset, and also Rhesus monkey. We are developing high sensitivity RF coils and a method to register MR, PET-CT and optical imaging. We are also performing biomedical studies using multi-nuclear MRI, and research into post-processing techniques such as statistical mapping.

Magnet of 7 Tesla MRI	brain of Rehsus Monkey (left : 7T MRI / right : 1.5T MRI)
In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage. 2004 Jul;22(3):1046-59.
Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations. NMR Biomed. 2004 Dec;17(8):532-43.

members