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Annual Report 2002-2003

Contents

Preface

    Preface

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PHYSICS

  1. Basic Study on Pulse Height Distribution of DOI Detectors Constructed of Stacked Crystal Elements
  2. DOI-PET Image Reconstruction with Accurate System Modeling That Reduces Redundancy of the Imaging System
  3. Basic Investigation of Data Acquisition System for Next Generation PET Scanner
  4. Improvement of the Depth-of-Interaction Detector for PET on Full Energy Pulse Height Uniformity
  5. Performance of a PET Detector with a 256ch Flat Panel PS-PMT
  6. The Polybinary Calibration Method for Radiotherapy Treatment Planning CT Systems
  7. Electron Density Measurement with Dual-Energy X-ray Computed Tomography
  8. Design and Performance of a Non-Destructive Beam Profile Monitor Utilizing Charge-Division Method at HIMAC
  9. Charge Fraction of 6.0 MeV/n Heavy Ions Measured with a Carbon Foil
  10. Characteristics of Fast Beam Switching for Spot Scanning
  11. Analytical Reconstruction Algorithm for Compton Cameras Applicable to Lower Gamma Energy
  12. Single Particle Irradiation System to Cell (SPICE) in the ElectrostaticAccelerator Building
  13. Responses of Two Types of Gamma Ray Directional Detectors

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CHEMISTRY

  1. Production of Semiquinone by Oxidation of paraMonosubstituted Phenols with Singlet Oxygen
  2. DNA Cleavage via Superoxide Anion Formed in Photoinduced Electron Transfer from NADH to γ-Cyclodextrin-Bicapped C60 in an Oxygen-Saturated Aqueous Solution
  3. Effects of Metal Ions Distinguishing between One-Step Hydrogen-and Electron-Transfer Mechanisms for the Radical-Scavenging Reaction of (+)-Catechin and Vitamin E Model
  4. Enhanced Radical-Scavenging Activity of a Planar Catechin Analogue
  5. Scavenging Property of the Indole Derivatives for the Nitrating Intermediate of Peroxynitrite
  6. Attenuation of the Ability of Cytochrome c for Caspase Cascade Activation due to Protein Nitration by Peroxynitrite

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BIO-MEDICAL SCIENCES

Biochemistry and Biophysics

  1. Disapp earance of Nuclear Binding Proteins Bound to The Far-Upstream Region of The Interleukin-1β Gene Immediately after Irradiation Of Mouse Macrophages
  2. DNA Cleavage via Superoxide Anion Formed in Photoinduced Electron Transfer from NADH to γ-Cyclodextrin-Bicapped C60 in an Oxygen-Saturated Aqueous Solution
  3. Effect of Oxidative Stress on Glutathione Redox Status in Mouse Measured by Simultaneous Determination of GSH and GSSG with HPLC
  4. Transient Increase of mRNA of Heme Oxygenase-1 in Rat Liver after a Whole-body X-irradiation
  5. Analysis of Unrejoined Chromosomal Breakage in Human Fibroblast Cells Exposed to Low- and High-LET Radiation
  6. Models for Mixed Irradiation with a 'Reciprocal-Time' Pattern of the Repair Function
  7. Effect of a Hypoxic Cell Sensitizer Dranidazole in Radiation-Induced Apoptosis of Mouse L5178Y Lymphoma Cells
  8. Synthesis and Evaluation of 4-Bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a Low Energy LUMO Orbital Designed as Brain Hypoxia-Targetting Imaging Agent
  9. Development of a Dielectric Equivalent Gel for Better Impedance Matching for Human Skin

Cell Biology

  1. Relationship Between Aberration Yield and Mitotic Delay in Human Lymphocytes Exposed to 200 MeV/u Fe-Ions or X-Rays
  2. Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ion
  3. Nitric Oxide-Mediated Bifunctional Bystander Effect Induced by Heavy-Ion Radiation in Human Salivary Grand Neoplastic Cells
  4. Radiation-induced Growth Inhibition in Transplanted Human Tongue Carcinomas with Different p53 Gene Status
  5. Granulocyte-Macrophage Colony-Stimulating Factor Controls the Proliferation and Differentiation of Mouse Epidermal Melanocytes from Pigmented Induced by Ultraviolet Radiation B
  6. Effects of Mutations in Ku80 Proteins on Ku-dependent DNA Repair
  7. Role of Reactive Oxygen Species in Cells Overexpressing Manganese Superoxide Dismutase
  8. Influence of Nitric Oxide on Cell-Cell Junctions of Mouse Mammary Epithelial Cells

Genetics

  1. Risk Factors Associated with Adverse Effects of Radiotherapy on Skin among 125 Breast Cancer Patients - Multi-leaf Collimators, Histological Evaluation, Immobilization Devices, or Source Energy of Irradiation -
  2. Chromosomal Instability and the Abrogated G2/M Arrest in X-irradiated MDS Cells
  3. γH2AX Foci Formation in X-irradiated Human Cells with Varying Radiosensitivity
  4. Expression Profiles of Genes Related with Radiosensitivity Indicating Strain Difference in Three Strains of Mice
  5. Gene Expression of Detoxifying Enzymes in AhR and Nrf2 Compound Null Mutant Mouse
  6. Radiation-induced chromosomal instability in lymphocytes of cancer patients
  7. Developmental Responses of Two Substrains of in Vitro Fertilized C57BL/6J Mouse Embryos to Oxygen and Amino acids
  8. Analysis of α-and β-tubulin Genes of Bombyx mori Using an EST Database
  9. Diminished Levels of Allelic Losses by Homologous Recombination in Radiation-hypersensitive Cells

Immunology,Pathology and Physiology

  1. Polymerase Chain Reaction with a Primer Pair in the 16S-23S rRNA Spacer Region for Detection of Mycoplasma pulmonis in Clinical Isolates
  2. Analysis of Protein Expression by Mammalian Cell Lines Stably Expressing Lactate Dehydrogenase-Elevating Virus ORF 5 and ORF 6 Proteins
  3. Murine Pre-B-Cell Lymphomas Following Injection of Plutonium Citrate in Comparison to MNU-Induced T-Lymphoblastic Lymphomas
  4. Life Span and Spontaneous Tumors Incidence of the Wistar Mishima (WM/MsNrs) rat

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Radiotoxicology

  1. Spin Trapping Reagents as Radioprotectors against Whole Body X-Ray Irradiation of Mice
  2. Adaptive Response in Embryogenesis: V. Existence of Two Dose-Rate Ranges for the Same Priming Dose to Adapt Fetal Mice
  3. Radiation-Induced Teratogenesis in the Late Period of Organogenesis in Mice: Dose Rate Effects
  4. Comparative Study on Tp53 Mutations in Rat Lung Tumors Induced by Inhalation Exposure to Alpha Emitters and X-ray Irradiation
  5. Pulmonary Carcinogenesis in the Rat Following Inhalation Exposure to Plutonium Dioxide in Comparison to X-ray Irradiation
  6. Specific Induction of Osteosarcomas in Different Mouse Strains Following Injection of Plutonium Citrate
  7. Induction of DNA Double Strand Breaks in Scid Cells by Carbon Ions
  8. Effects of a Human Dose of Ca-DTPA on Removal of Different Amounts of Plutonium from the Rat

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CLINICAL RESEARCH

  1. Imaging of Each Compartment in PET Dynamic Study with Dual Tracer Injection and 2-Input Compartment Model
  2. Regional Differences of Relationships between Atrophy and Glucose Metabolism of Cerebral Cortex in Patients with Alzheimer's Disease
  3. Registration of SPECT, PET and/or X-ray CT Images in Patients with Lung Cancer
  4. Development of a Method of Clustering Multiple Function of the Brain in Hemodynamic Disease with Positron Emission Tomography.
  5. A Scheduling System for Patient Treatment by Heavy Ion Radiotherapy
  6. High Levels of Serotonin Transporter Occupancy with Low Dose Clomipramine in Coparative Occupancy Study with Fluvoxamine Using Positron Emission Tomography
  7. No Association Between Genotype of the Promoter Region of Serotonin Transporter Gene and Serotonin Transporter Binding in Human Brain Measured by PET
  8. Inhibitory Effect of Hippocampal 5-HT1A Receptorson Human Explicit Memory
  9. The FNCA 2002 Workshop on Radiation Oncology
  10. Automated Synthesis of the Ultra High Specific Activity of [11C]Ro15-4513 and Its Application in an Extremely Low Concentration Region to an ARG Study
  11. How to Increase the Reactivity of [18F]Fluoroethyl Bromide: [18F]Fluoroethylation of Amine, Phenol and Amide Functional Groups with [18F]FEtBr, [18F]FEtBr/NaI and [18F]FEtOTf
  12. Preclinical Biological Assessment of Proton and Carbon Ion Beams at Hyogo Ion Beam Medical Center.
  13. Significance of Fractionated Irradiation for the Biological Therapeutic Gain of Carbon Ions
  14. Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma
  15. Initial Medical Management of Patients Severely Irradiated in the Tokai-mura Criticality Accident

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ENVIRONMENTAL SCIENCE

  1. The Involvement of Cell Cycle Checkpoint-mutations in the Mutagenesis Induced in Drosophila by a Longer Wavelength Light Band of Solar UV.
  2. Action Spectra of Apoptosis Induction and Reproductive Cell Death in L5178Y Cells in UV-B Region
  3. Database of Calculated Values of Retention and Excretion for Members of the Public Following Acute Intake of Radionuclides
  4. 239+240Pu Fluxes on the Continental Margin of the East China Sea
  5. Biokinetics of Radiotellurium in Rats
  6. Micro-PIXE Application for Analysis of Elemental Distribution in Plant Root
  7. Elemental Imaging of Rat Testis by Micro-PIXE Analysis
  8. Hyperaccumulation of Radioisotopes in Marine Algae
  9. Elemental Distribution in Organs of Medaka, Orysias laptipes, Burdened with X-ray Irradiation and Salty Water Breeding Determined by PIXE Analysis
  10. Cancer Risks among Radiologists and Radiologic Technologists: A Review of Epidemiological Studies
  11. Relationships between Radiocesium and Stable Cs in Mushrooms and Plants Collected in Forests with Different Contamination Levels
  12. Determination of Trace Rhenium in River Water Samples by Q-ICP-MS and HR-ICP-MS
  13. Global Fallout Technetium-99 Distribution and Behavior in Japanese Soils
  14. Changes in Physicochemical Forms of Technetium in the Water Covering Paddy Soils
  15. Bio-kinetics of Radon Ingested from Drinking Water
  16. Simple, Discriminative Measurement Technique for Radon and Thoron Concentrations with a Single Scintillation Cell
  17. A New Passive Integrating Radon and Thoron Monitor

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SPACE SCIENCE

  1. Interim Report of Cosmic Ray Doses in Airplanes Measured by a Pocket Dosimeter
  2. The Effect of High LET Radiation Is Compromised in NHEJ Deficient Human and Rodent Cells
  3. Pion-Emission Cross Section in Finite Nuclei at Cosmic Ray Proton Energy
  4. Resonance Model for Radiation Action
  5. IC CHIBAN (InterComparison for Cosmic-rays with Heavy Ion Beams At NIRS) Project
  6. Real Time Radiation Measurement by Liulin-4J Spectrometer at High Altitude
  7. Preventive Effects of Running Exercise on Bones in Heavy Ion Particle Irradiated Rats
  8. Genomic Instability in Mutation Induction on Normal Human Cells Exposed to Chronic Low-dose Radiation in Heavy Ion Radiation Field
  9. LET and Ion Species Dependence of Cell Killing, Mutation Induction and Chromosome Damage on Normal Human Fibroblasts
  10. Influence of the Shielding on the Space Radiation Radiobiological Effectiveness.
    11. II. Chromosomal Aberrations
  11. Simultaneous Exposure of Mammalian Cells to Heavy Ions and X-rays

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INTERNATIONAL COOPERATION

  1. International Activities of NIRS

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APPENDIX

  1. PUBLICATIONS
  2. List of Keywords
  3. Author Index
  4. Organization and Staff

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NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
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