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Annual Report 2001 - 2002

Contents

Preface

    Preface

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PHYSICS

  1. Count Rate Analysis of GSO-DOI PET Scanners
  2. Algebraic 2D PET Image Reconstruction Using Depth-of-Interaction Information
  3. A Depth-of-Interaction Detector for PET with GSO Crystals Deped with Different Amount of Ce
  4. Improvement of the HIMAC Treatment System with the Layer-Stacking Conformal Irradiation Method
  5. Quantitative Computed Tomography Using Dual-Energy Monochromatic X-rays
  6. Fast Beam Cut-Off Method in RF-knockout Extraction for Spot Scanning
  7. The Scanning Micro-Beam PIXE Analysis Facility at the Electrostatic Accelerator Building
  8. Development of Very Strong Magnet by New Teqniqus
  9. Skin Temparature Changes in Remote Action Experiment
  10. New Ganma-Ray Directional Detectors with Different Types of Scintillators

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CHEMISTRY

  1. DMPO-mediated Cinversion of Singlet Oxygen to Hydroxyl Radical in the Presence of Phenolic Compounds
  2. Dose-and Time-Dependence of Radiation-Induced Nitric Oxide Formation in Mice as Quantified with Electron Paramagnetic Resonance
  3. Functional Modification of Cytochrome c by Peroxynitrite in an Electoron Transfer Reaction

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BIO-MEDICAL SCIENCES

Biochemistry and Biophysics

  1. Enhancment of Early Retrotransposon (ETn) RNA in Myeloid Leukemia Cells from C3H/He Mice
  2. In Vivo Radioprotection of Stable Free Radical Nitoxides, Carbamoyl- and Metoxycarbonyl-PROXYL againist Whole Body X-Ray Irradiation of Mice
  3. Hydroxyl Radical Formation Mediated by Spin Trapping Agent, DMPO, in Uroporphyrin Photodynamic Reaction in the Presence of Biological Reductants
  4. Acute Induction of Heme Oxygenase-1 in Rat Liver by a Whole-Body X-ray Irradiation
  5. Involvement of Protein Kinase C in Radiation-Induced Apoptosis Signaling Pathways in Murine Thymic Lymphoma Cells (3SBH5 Cells)
  6. Difference among Heavy Ion Beams in Cell KIlling and Mutation Induction
  7. Medium-Mediated Bystander Effects on HSG Cells Co-Cultivated with Carbon Beam-Irradiated Cells

Cell Biology

  1. Expression, Subcellar Localization and Chromosome Localization of Hamster Ku70 and Ku80
  2. Endothelins Control the Poriferation and Differentiation of Murine Melanocytes from UVB-Induced Pigmented Spots
  3. Effects of Nitric Oxide on Sertoli Cell Tight Junction-Associated Proteins
  4. Chemically Induced Premature Chromosome Condensation in Human Fibroblast Cell Lines: Fundamental Study for Applications to the Biodosimetry of Local Exposure
  5. Targeted Disruption of Np95 Gene Renders Murine ES Cells Hypersensitive to DNA Damaging Agents and DNA Replication Blocks
  6. Significance of Fractionated Irradiation for the Biological Therapeutic Gain of Carbon Ions
  7. Time-Course of Reoxygenation in Experimental Murime Tumors after Carbon-Beam and X-Ray Irradiation
  8. Chromatid Breaks Induced in Normal Human Cells by Heavy Ions at Initial, Metaphase and Interphase States
  9. Hsp25 Regulates the Expression of p21Waf1/Cip1/Sdi1 through Multiple Mechanisms

Immunology and Hematology

  1. Analysis of the Receiver's EEG in Remote Perception Task
  2. Age-Related Changes in Bone Mineral Density, Cross-Sectional Area and Strength at Different Skeletal Sites in Male Rats

Pathology and Physiology

  1. Reduced Sensitivity to and ras Mutation Spectrum of N-Ethyl-N-Nitrosourea-Induced Thymic Lymphomas in Adult CB-17 Scid Mice
  2. Characyteristic Association between K-ras Gene Mtation with Loss of Heterozygosity in X-Ray-Induced Thymic Liphomas of the B6C3F1 Mouse
  3. Incidence of Pyometra in Colony-Raised Beagle Dogs
  4. Production of Virus-Specific Antiserum Corresponding to Sequences in the Lactate Dehydrogenase-Elevating Virus ORF6 Protein
  5. Development of Purkinje Cells in the Cerebellum of xpg-Deficient Mice
  6. Histogenesis of Heterotopic Gray Matter in the Brain of the Mouse Prenatal Exposed to X-Ray Irradiation

Genetics

  1. Dose-Dependent Increse of Spi Mutations in the Spleen and Liver of Atm-Disrupted Mice Following X-Ray Irradiation
  2. Expression Profile Using HiCEP
  3. Comparison Study on Genome Coding DNA-Dependent Protein Kinase between Chikens and Mice
  4. Disruption of Xpg Increses Spontaneous Mutation Frequency, Particularly A:T to-C:G Transversion
  5. A New Technique to Prevent Self-Ligation of DNA
  6. The Trial Study for Establishment of New Mutant Rat Strains Using the Chemical Mutagen
  7. Characterization of Gene in Respoionse to Irradiation through Systematic Transcripyome Analysis
  8. Analysis of Genetic Differences in Radiation Sensitivity Using Animal Models
  9. A Large-Scale Gene Expression Analysis of Radiosensitive and Radioresistant Rats Exposed to Ionizing Radiation
  10. Radiation Sensitivity of 49 Cultured Human Cancer Cell Lines
  11. Relationship between Cellular Radiosensitivity and DNA Damage Measured by Come Assay
  12. Amino Acid Substitution of the Largest Subunit of Yeast RNA Polymerase II: Effect of a Temperature-Sensitivity Mutation Related to G1 Cell Cycle Arrest
  13. Rederivation of Infected Mice by Embryo Transfer Technique

Radiotoxicology

  1. Effects of D-Penicillamine and Ca-DTPA on Removal of Radiocobalt in Rats
  2. Effects of CBMIDA on Removal of Uranium in Rats
  3. DTPA Treatment for Removal of Inhaled Plutonium Nitrate in Rats
  4. Immunohistochemical Study on Cellular Origins of Rat Lung Tumors Induced by Inhalation Exposure to Plutonium Dioxide and by X-Ray Irradiation
  5. Induction of Microuclei in Rat Alveolar Epithelial Cell Line by Alpha Particle Irradiation
  6. Involement of p53-Dependent Apoptosis in Radiation Teratogenesis and in the Radioadaptive Response in the Late Organogenesis of Mice

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CLINICAL RESEARCH

  1. Experiences of Carbon Ion Radiotherapy at NIRS
  2. The Dose-Volume Histogram Analysis for Pelvic Tumor Using Carbon Ion Radiotherapy
  3. Second Cancer Following Radiation Therapy for Uterine Cervical Carcinoma
  4. Usefulness of 3D Ultrasonography in Diagnosis of Hepatocellular Carcinoma and Its Invasively Growing Lesion: Deciding a Precise Target Volume in Radiation Therapy
  5. Cytokine Responses Detected in Blood from Cancer Patients Given X-Ray or Carbon Ion Therapy
  6. Objective Assessment of Cranial Nerve Neuropathy by Heavy Ions
  7. Allelic Loss of Chromosome 2 in Human Oral Squamous Cell Carcinoma: Correlation with Lymph Node Metastasis
  8. Clinical Application of Autoactivation PET Imaging Derived from C-12 Ion Radiotherapy and Its Fusion Imaging with Therapy Planning CT
  9. Funtional Diagnosis of Cancer Using PET
  10. The Cancer Functional Diagnosis and the Evaluation of Therapeutic Effects Using Magnetic Resonance Imaging and Spectroscopy
  11. Synthesis and Preliminary Evaluation of [18F]FEtP4A, a Promising PET Tracer for Mapping Acetycholinesterase in vivo
  12. Effect of Donepezil on Brain AChE Activity in Patients with Alzheimer's Disease Measured by PET
  13. Reference Tissue-Based Kinetic Analysis of [11C]MP4A PET Data without Arterial Input Function
  14. Brain N-acetylaspartate Is Elevated in Pelizaeus-Merzbacher Desease with PLP1 Duplication
  15. The Measurment of the Electrical Properties of Human Skin and the Variation among Subjects with Certain Skin Conditions
  16. Decresed Dopamine D2 Receptor Binding in the Anterior Cingulate Cortex in Schizophrenia
  17. Development of an ECR Ion Source for Carbon Ion Therapy
  18. Evaluation of Functional Changes in the Cerebral Cortex with Clustering: Multi-Functional PET Images Taken Pre- and Post Operation
  19. A Medical Image and the Database Archiving System at Research Center for Heavy Ion Therapy in NIRS

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ENVIRONMENTAL SCIENCE

  1. Final Report on Dose Estimation for Three Victims of JCO Accident
  2. Sensitivity to Thoron on Passive Radon Detectors
  3. Am-241 as a Metabolic Tracer for Inhaled Plutonium Nitrate in External Chest Counting
  4. Isotope Ratios of Uranium in Soil Samples Using Thermal Ionisation Mass Spectrometry Equipped with a WARP Filter
  5. Cell- Specific Distribution of Trace Elements in Rat Testis
  6. Estimaion of Dietary 232Th, 238U, Cesium and Strontium in Vietnamese People from Different Geological Regions
  7. Determination of Rhenium in Rock Samples by ICP-MS
  8. Low-level Technetium-99 Determination in Soil Samples by ICP-MS
  9. Effects of Ionizing Radiation on Movement Behavior of Euglena gracilis
  10. Determination of U and Pu Isotopes in Enviromental Samples by Inductively Coupled Plasma Mass Spectrometry
  11. Trace and Natural Radioactive Elements Contents in the Bangladeshi Soils near Industrial Area of Dhaka
  12. Epidemiological Investigations of the Residents Nearby Nuclear Power Plants in Japan: Progress and Future

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SPACE SCIENCE

  1. Genomic Instability in Mutation Induction on Norman Human Cells Exposed to Chronically Low-Dose Radiation in Heavy Ion Radiation Field
  2. LET and Ion Species Dependence of Cell Killing and Chromosome Damage on Normal Human Fibroblasts
  3. Conservative Evaluation of Space Radiation Dose Evaluation Using the Glow Curve of 7LiF:Mg,Ti(TLD-700)

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APPENDIX

  1. Publications
  2. List of Keywords
  3. Author Index
  4. Organization and Staff

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NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
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