66. The Cancer Functional Diagnosis and the Evaluation of Therapeutic Effects Using Magnetic Resonance Imaging and Spectroscopy

Masahisa Koga, Kyosan Yoshikawa, Takayuki Obata, Jun-etsu Mizoe and Hiroo Ikehira

Keywords: magnetic resonance spectroscopy(MRS), positron emission tomography(PET).

Thirty seven patients with abnormal T2-elongated space showing a brain lesion in magnetic resonance imaging were studied with multi-slice proton magnetic resonance spectroscopic imaging (multi-slice ¹H-MRSI) and positron emission tomography(PET). MRS images were obtained by combinating volume-selective excitation with phase encoded acquisition. Choline maps were created and compared with PET maps of methionine metabolism. Choline signal elevation seen in brain neoplasms was associated with increased cellular proliferation. Elevation of choline signal seemed most cases of regrowth of brain tumor, whereas loss of choline signal showed brain necrosis (Figs. 28-30).

Fig.28. MRI: glioblastoma multiforme	Fig.29. MRSI choline imaging	Fig.30. PET: C-11 Methionine