51. Effects of D-penicillamine and Ca-DTPA on Removal of Radiocobalt in Rats
Satoshi Fukuda, Haruzo Iida,
Yumi Abe* and Hiroki Yoshida*
(*Tokyo Nuclear Service Co. Ltd.)
Keywords: D-penicillamine, Ca-DTPA, removal, radiocobalt, daily recommended human dose
Based on a medical treatment schedule for humans, the effects of D-penicillamine and Ca-DTPA on the removal of radiocobalt were examined in rats. Rats were pre-injected with radiocobalt and then treated with D-penicillamine alone via an oral route, Ca-DTPA alone via an intraperitoneal injection, or both compounds at the same time at doses equivalent to the daily recommended human dose. The compounds were administered for 3 days, beginning with or 1h after radiocobalt injection on the first day. The radioactivity levels of the whole body of rat, urine and feces were measured at intervals of 24 h. On day 4, the rats were sacrificed in order to obtain blood and organs. When D-penicillamine was administered with and 1 h after injection of radiocobalt, the whole body activity was reduced to 9.6 and 79.0% of that of the control, respectively, in the Ca-DTPA-alone groups and to 54.8% in the group in which both compounds were administered 1 h after radiocobalt. In the D-penicillamine-alone groups, the activity levels were reduced to 33.6 and 56.6% with and 1h after radiocobalt injection, respectively (Fig. 24). In conclusion, the results of this study indicate that D-penicillamine is useful in treating a person contaminated with radiocobalt in an accident.
Publications:
Fukuda, S., Iida, H., Abe, Y. and Yoshida, H.: J. Health Phys., 36, 323-328, 2001
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