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Annual Report

Contents

PREFACE

    PREFACE

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PHYSICS

  1. Physiological Changes in Remote Action Experiment
  2. Effects of External End-Shields for Positron Emission Tomography
  3. A Fast Algebraic Image Reconstruction Method for a Clinical PET Scanner
  4. Spot Scanning Using Radioactive 11C Beams for Heavy-Ion Radiotherapy
  5. First Observation of the Ion-Pumping Effects in a Pulsed Penning Source
  6. Simultaneous Measurement of Coming Directiopns and Energies of Gamma-RaysUsing a Tandem Detectors

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CHEMISTRY

  1. Phenolic Compounds Catalyze the Conversion of Singlet Oxygen into Hydroxyl Radical in the Presence of DMPO
  2. Induction of Superoxide in Glioma Cell Line U87 Stimulated with Lipopolisaccharideand Interferon Gamma: ESR Using a New Flow-Type Quartz Cell
  3. Improved Synthesis of 5-tert-Butoxycarbonyl5-methyl-1-pyrroline N-oxide

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BIO-MEDICAL SCIENCES
Biochemistry and Biophysics

  1. Potent Preventive Action of Curcumin on Radiation-Induced Initiation of Mammary Tumorigenesis in Rats
  2. A Possible Mechanism of Inactivation of C17-C20 Lyase in Rat Ovary by a Single Injection of hCG
  3. Low-Dose Irradiation Influences Ca2+ Signaling in Cultured Rat Hepatocytes
  4. X-rays or Heavy Ion Radiation-Induced Chromosome Damage on an Ionizing Radiation Sensitive Mutant Mouse Cell Line as Analyzed by Atomic Force Microscope
  5. Reactivitry of Nitroxyl Spin Probes with Reactive Oxygen Species
  6. The Preliminary Experiments for Clinical Multi Nuclei MRS Using a Commercial MRI System

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BIO-MEDICAL SCIENCES
Cell Biology

  1. Effects of Antibodies of Growth Factors and Cytokines on the Proliferation of Cultured Epidermal Melanoblasts and Melanocytes Derived from Skins of UVB-Induced Pigmented Spots in Mice
  2. Regulation of the Catalase Gene Promoter in Hydrogene Peroxide-Resistant HP100 Cells
  3. Modulation by Curcumin of NF-KB Activation in Cultured Rats Mammary Gland
  4. Allocyclic X Chromosome Visualized by Drug-Induced Premature Chromosome Condensation
  5. Relative Biological Effectiveness of 235 the MeV Proton Beam at the National CancerCenter Hospital East Koichi Ando, Yoshiya Furusawa, Masao Suzuki, Kumie Nojima, Hydeyuki Majima, Sachiko Koike,
  6. Radiobiological Effects of Heavy-Ion Beams on Cells

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BIO-MEDICAL SCIENCES
Immunology and Hematology

  1. Cytogenetic and Cellular Events during Radiation-Induced Thymic Lymphomagenesis in p53 Heterozygous(+/-) B10 Mice

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BIO-MEDICAL SCIENCES
Pathology and Physiology

  1. Development of Thymic Lymphomas by Ionizing Radiation in Scid Mice
  2. Radiation-Associated Loss of Heterozigosity at Ikaros Allele and Ikaros Mutation in Murine Thymic Lymphomas
  3. RT-Nested PCR Diagnosis of Mouse Hepatitis Virus Contamination in ImmunocompromisedMouse Population
  4. Comparison of Respiratory Lesions in C3H and C3H-Scid Mice Experimentally Infected with CAR Bacillus
  5. Therapy of Radiation Damage to Normal Tissues with Selective Inhibitors of Cyclooxyygene-2 : YM177 Tends to Reduce Mouse Mortality from Haemopoitic Syndrome

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BIO-MEDICAL SCIENCES
Genetics

  1. The Nucletide Sequence of Schizosaccharomyces pombe Chromosome III
  2. A Mutation in the Largest ( Catalytic ) Subunit of RNA Polymerase II and Its Relation to the Arrest of the Cell Cycle in G1 Phase
  3. Dimerization and Nuclear Localization of Ku70 and Ku80 Proteins
  4. Phosphorylation Sites of NPAT by CyclinE/CDK2 Complex
  5. Analysis of Functiopal Regions for the Nuclear Localization of NPAT
  6. Analysis of Transcriptional Control Region NPAT and ATM Genes
  7. Brain Structures of A Medaka Mutant, el ( eyeless ), in Which Eye Vesicles Do Not Evaginate
  8. Cryopreservation and Transport of Mouse Spermatozoa at -79oC

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BIO-MEDICAL SCIENCES
Radiotoxicology

  1. Effective Timing of Initial Administration of Ca-DTPA for Removal of Inhaled Plutonium Nitrate in Rats

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CLINICAL RESEARCH

  1. Serotonin 5-HT2 Receptors in Schizophrenic Patients as studied by Positron Emission Tomography
  2. Brain Cholinergic Function in Denmentia with Lewy Bodies and Alzheimer's Disease as Measured by Positron Emission Tomography
  3. Development of an Automated System for the Quick Production of 13N-Labeled Componds with High Specific Activity Using Anhydrous {13N}NH3
  4. Co-operative Study to Establelish a Lung Cancer Screening System Using CT Units
  5. Clinical Application of Autoactivation PET Imaging Derived from C-12 Ion Therapy
  6. Functional Diagnosis and Evaluation of Therapeutic Effects of Cancer Using PET
  7. Quantitative Estimation of Brain Atorophy and Function with PET and MRI Two-Dimensional Projection Images

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ENVIRONMENTAL SCIENCE

  1. Determination of 32P in Urine for Early Dose Estimation of Three Victims in the JCO Criticality Accident
  2. Determination of 32P in Hair of Three Victims in JCO Criticality Accident and Esatimation of the Fast Neutron Fluence the Body Surface
  3. Tokai-mura Criticality Accident: Whole Body Distribution of 45Ca and 32P in Bone of the Victims Exposed to High-Dose Neutron Irradiatiion
  4. A Quality Assurance Aspect of IAEA-RCA Reference Asian Man Project ( Phase 2 ): Ingestion and Organ Content of Trace Elements of Importance in Radiological Protection
  5. Contribution of 18 Food Categories to Intakes of 232Th and 238U in Japanese
  6. A Review for the Epidemiological Study for Health Monotoring of Potential Risk from Radiation Exposure near the Nuclear Power Plantp in Japan
  7. Estimation of Internal Dose by Blood Analysis for Exposure to Tritium in Various Chemical Forms
  8. Bioassay for Neutron-Dose Estimations of Three Patients in the JCO Criticality Accident in Tokai-mura by Measuring -ray Emitters with a Liquid Scintillation Counter
  9. Ecologically Responsive Phenomena of the Aquatic Microcosm Systemto Ultra Violet C
  10. Determination of Uranium Isotopes by ICP-MS in Soil Core Samples Collected around the Reconversion Facilities
  11. Measurment of Technetium-99 in Marshall Islands Soil Samples by ICP-MS
  12. Radon and Its Progeny in Office Buildings
  13. Dose Evaluation and Effective Dose Estimation for Multi-Detector CT
  14. Elution Behavior of Tc and Re through a Tc-Selective Chromatographic Resin Column
  15. Fate of Two Important Radionuclides in the Coastal Seas of Japan and Resultant Dose from Intake through Fishery Products

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SPACE SCIENCE

  1. Cellular Response in Normal Human Cells Exposed to Chronically Low-Dose Radiation in Heavy Ion Radiation Field
  2. Radiobiological Effectivness of Different HZE Beams on Cells
  3. Development of Radiation Monitors and Detectors for Cosmic Rays of These Secondary Particles in Space Environmental and High Altitude
  4. Effective Dose Equivalent on the Ninth Shuttle-Mir Mission ( STS-91 )
  5. vMolecular Dynamics Simulation of a DNA Containing a Single Strand Braek

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APPENDIX

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NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
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