36. Effective Timing of Initial Administration of Ca-DTPA for Removal of Inhaled Plutonium Nitrate in Rats
Satoshi Fukuda, Haruzo Iida, Yuji Yamada, Kumiko Fukutsu and Akira Koizumi
Keywords: Ca-DTPA, plutonium nitrate, first injection time, removal effect, inhalation, rats
The effective timing of the initial injection of Ca-DTPA and the subsequent
early treatment for removal of inhaled plutonium nitrate were studied in rats.
One group of rats that had inhaled plutonium nitrate received an intraperitoneal
injection of Ca-DTPA at a daily dose of 150
mol/kg
for 3 days, beginning at 0.5, 1, 2, 6, or 12 h after inhalation of plutonium;
a second group received an injection at a daily dose of 30 mol/kg
(the daily recommended dose for humans), beginning 1h after plutonium inhalation.
A third group served as the control with no treatment. During the experiment,
the urine and feces were collected every day; on day 4, the rats were sacrificed
and dissected to measure plutonium concentration in blood and various organs.
The first administration of Ca-DTPA (150mol/kg)
at 1-6 h after inhalation initiated an increase in urinary plutonium excretion
during the first 24 h following inhalation and also resulted in significant increases
of urinary plutonium excretion for up to 3 days following the treatment (Fig.12).
The increase was measured in comparison to the urinary levels of the rats that
had treatment initiated at 0.5 h or 12 h. In the group that was given 30 mol/kg
Ca-DTPA, higher urinary plutonium excretion was found, compared to the control
group; however, these levels were lower than those of the group that was administered
a dose of 150 mol/kg. Although
the retention rates in various organs of the Ca-DTPA treatment groups varied compared
to the corresponding organs in the control group, the changes were very slight.
The results indicate that Ca-DTPA administration within 1-6 h after exposure to
plutonium is effective to increase the urinary excretion of plutonium in rats
Publication:
Fukuda, S., Iida, H., Yamada, Y., Fukutsu, K. and Koizumi, A.: J. Health Phys.,
36, 25-30, 2001.
| Fig.12. | Amount of plutonium excreted in the urine for 3 days after Ca-DTPA injection. Each vertical bar represents the mean + 1SE. |