43. Progesterone Receptor Is Favorable Prognostic Factor of Radiation Therapy for Adenocarcinoma of the Uterine Cervix

Yoshiyuki Suzuki,M.D., Takashi Nakano,M.D Atsuko Abe,M.0., Shinroku Morita,M.D Hirohiko Tsujii,M.D., and Kuniyuki Oka,M.0

Keywords: adenocarcinoma, radiation therapy

The prognostic significance of the expression of estrogen receptors (ER) and progesterone receptors (PgR) in adenocareinoma of the uterine cervix has been controversial. Hence, the relationship between the expression of the hormone receptors and clinical outcome was evaluated for patients with adenocarcunoma treated with radiation therapy alone. This study unvolved 66 patients with cervical adenocarctnoma consisting of 44 adenocarcinomas and 22 adenosquamous cell carcinomas. They received radiatuon therapy at the NIRS Hospital between 1962 and 1993. The mean age of the patients was 62.O12.0 years (range, 36-82 years). The numbers of patients with stage I , II , III and IV diseases were 7, 17 27,and 15, respectively. Their FIR and PgR statuses were investigated immunohistochemically for biopsy specimens excised from the cervical tumors before radiation therapy.

ER staining was positive in 12 patients (19%) ER status did not correlate with the 5-year cause specific, local control, and disease free survivals. PgR staining was positive in 12 patients (19%). The disease-free survival rate of PgR positive patients was significantly higher than that of I'gl{ negative patients (p=O.044). Although PgR status did not reach statistical significance in relation to the 5-year cause specific survival and local control, the better survival was due to less local recurrence rather than distant metastasis. The present study suggested that PgR status was associated with prognosis after radiation therapy for adenocarcinoma of the uterine