60. Removal of Strontium by the Chelating Agent, Acethylamino Prophylidene Diphosphonic Acid, in Rats

Satoshi Fukuda, Haruzo Iida, Yueming Yan^*, Yuyuan Xie^* and Wenzie Chen^*
(^*Shanghai Institute of Materia Medica, China)

Keywords: strontium, APDA, parenteral administration, oral administration, rats

Studies on the effects of the chelating agent, calcium acetylamino propylidine diphosphonic acid (Ca-APDA) on the removal of radioactive strontium with two administration modalities were carried out in rats. The parenteral (intraperitoneal) administration of 150, 300 and 600 mg/kg Ca-APDA was carried out for 3 days, 10 min after exposure of the animals to the strontium injection. On the first day post-treatment, the retention of strontium in the whole body decreased to 90.1%, 83.9% and 35.1% of that of the control level, respectively. The strontium deposited in femur of the 600 mg/kg Ca-APDA group was lowered to 28.4 % of the control value. A single oral dose of 600 mg/kg Ca-APDA administered simultaneously with, or 10 min after, oral administration of strontium, gave a reduction of radionuclide retention in the whole body after 1 day to 42.9%, or 31.9% of the control, respectively; meanwhile the strontium deposited in the femur was reduced to 16.9% or 29.3% of the control. In conclusion, the results indicate the efficacy of the new agent, Ca-APDA, to remove radioactive strontium from the body, or to inhibit the strontium intestinal absorption, in radio-strontium contaminated individuals.

Publications:
Fukuda S. and Iida H.: Health Phys. 76, 489-494, 1999.