59. Effects of Four CBMIDA Analogues on Removal of Plutonium in Rats

Satoshi Fukuda and Haruzo Iida

Keywords: plutonium, CBMIDA analogues, oral administration, injection, rats

We previously reported that the injection of a newly developed chelating agent, catechol-3, 6-bis(methyleiminodiacetic acid) (CBMIDA), removes plutonium particularly from the bones, more effectively than DTPA in rats. Nevertheless, the removed plutonium is later redistributed to the kidney, an undesirable phenomenon, in chelation therapy. Therefore, we wanted to survey the effects of four new analogues of CBMIDA on the removal of plutonium in rats and compare them with CBMIDA. After the intravenous injection of plutonium, CBMIDA and its analogues were administered daily, for 2 weeks by intraperitoneal injection or oral administration. The gathered data indicated that the intraperitoneal administration of two analogues significantly decreased the amounts of plutonium in the bones and liver (p<0.01), and the amounts in the spleen, testis and kidney were also reduced. In conclusion, the results indicate that among the tested agents, these two chelating agents present useful characteristics for chelation therapy in individuals contaminated with plutonium.

Publications:
Fukuda s. and Haruzo Iida: J. Health Phys., 33, 331-336, 1998.