The 7th Japan-France Workshop on Radiation Biology : NIRS

Date:	October14-16, 2008
Venue:	2nd Floor, Research Building for Charged Paritcle Therapy National Institute of Radiological Sciences 4-9-1 Anagawa, Inage-ku,Chiba-shi,Chiba,263-8555 ,Japan
Organizers:	National Institute of Radiological Sciences, Chiba, Japan Commissariat à l' Énergie Atomique[Life Science Division],France
Registration Fee:	Free No need to register in advance
Inquiries:	National Institute of Radiological Sciences Dept. of Planning and Management Education and International Cooperation Section 4-9-1 Anagawa, Inage-ku, Chiba-shi Chiba 263-8555, Japan TEL : +81-43 (206) 3024 FAX : +81-43 (206) 4061 e-mail: kokusai@nirs.go.jp
Other:	Poster (PDF 1,559KB) Program (PDF 112KB)

PROGRAM
Day 1: Tuesday, October 14, 2008
	Opening Ceremony
9:00-9:30	Welcoming remarks	Yoshiharu Yonekura (NIRS)
	Opening remarks	Pierre Legrain (CEA) Ryuichi Okayasu(NIRS)
	Greetings	Jean-Louis Armand (Embassy of French) Pierre-Yves Cordier(Embassy of France)
	Group photography
	Session1: Radio-carcinogenesis	Chair :Ryuichi Okayasu(NIRS) Bernard Lopez (CEA)
9:45-10:10	Methods in differential phosphoproteomics: potential application to radio-carcinogenesis	Eric Quéméneur(CEA-IBEB)
10:10-10:35	Specific gene expression profiles in post-radiotherapy-induced-thyroid tumors.	Sylvie Chevillard(CEA-IRCM)
10:35-10:50	Coffee Break (15)
10:50-11:15	Cellular and molecular characterization of pre-lymphoma cells developing in the atrophic thymus of gamma-irradiated mice	Ryo Kominami (Niigata Univ.)
11:15-11:40	p53 dependent S checkpoint and avoidance of mutation and possibly cancer during embryonal development in mice	Ohtsura Niwa(NIRS)
11:40-13:30	Lunch break (110)
	Session 2: Heavy ions for cancer therapy	Chair: Iwao Kanno (NIRS) Eric Quéméneur (CEA)
13:30-14:15	Keynote lecture Current status and future plans of carbon ion radiotherapy at NIRS	HirohikoTsujii (NIRS)
14:15-14:40	Carbon ion radiotherapy in bone and soft tissue sarcomas	Tadashi Kamada (NIRS)
14:40-15:05	Biological effects of heavy ions near the Bragg peak	Teruaki Konishi (NIRS)
15:05-15:20	Coffee Break (15)
15:20-15:45	Antiarrhythmic effect of single heavy-ion irradiation for ventricular fibrillation of diseased rabbit heart	Mari Amino (Tokai Univ.)
15:45-16:10	Cytogenetic alterations induced by heavy ions	Laure Sabatier (CEA-IRCM)
17:30-	Welcome reception

Day 2: Wednesday, October 15, 2008
	Session 3: DNA damage and repair	Chair: Ohtsura Niwa(NIRS) Francois Boussin (CEA)
9:00-9:25	Identification and characterization of interaction sites of Mlh1 protein, an essential factor from Mismatch repair (MMR) associated with frequent colon cancer	Jean-Baptiste Charbonnier (CEA-IBITEC-S)
9:25-10:10	Keynote lecture Responses of base excision repair proteins to oxidative stress	Pablo Radicella (CEA-IRCM)
10:10-10:35	Xpc-deficiency results in tissue-specific genomic instability in mice	Tetsuya Ono (Tohoku Univ.)
10:35-10:45	Coffee Break (10)
10:45-11:10	DNA double strand break repair under high and low LET radiation	Ryuichi Okayasu (NIRS)
11:10-11:35	Dynamics of higher order nuclear architecture upon DNA damage	Satoshi Tashiro (Hiroshima Univ.)
11:35-11:45	Coffee Break (10)
11:45-12:10	Double strand break repair in mammalian cells: The alternative non-homologous end-joining	Bernard Lopez (CEA-IRCM)
12:10-12:35	Proteasome assembly chaperones: new tools for cancer therapy?	Anne Peyroche (CEA-IBITEC-S)
12:35-14:10	Lunch break (95)
	Session 4: Low dose effects	Chair: Kazuo Sakai (NIRS) Sylvie Chevillard (CEA)
14:10-14:35	Regulation of the p21 gene promoter in response to clinically relevant doses of radiation	Mitsuru Nenoi (NIRS)
14:35-15:00	Adaptive response and high-LET radiation	Guillaume Vares (NIRS)
15:00-15:10	Coffee Break (10)
15:10-15:55	Keynote lecture "RISC-RAD" Improving science behind radioprotection: one example of Consequences of single DSB near telomere in human cells	Laure Sabatier (CEA-IRCM)
15:55-16:20	gpt delta transgenic mice for in vivo genotoxicity assays: application to analysis of combined effects of radiation and chemicals	Takehiko Nohmi (NIHS)
19:00-	French reception

Day 3: Thursday, October 16, 2008
	Session 5: Stem Cells	Chair:Sadayuki Ban(NIRS) Pablo Radicella (CEA)
9:30-9:55	Selective segregation of chromosomes in neural stem cells: Re-examination of the immortal strand hypothesis	Seiji Kodama (Osaka Prefecture Univ.)
9:55-10:20	Clustered gonocyte apoptosis in cultured fetal rat testes Induced by accelerated heavy-ion-irradiations and its possible mechanisms	Bing Wang (NIRS)
10:20-10:45	Effect of radiation on protein expression along the crypt-villus axis in mouse intestinal epithelial cells	Misao Hachiya (NIRS)
10:45-11:00	Coffee Break (15)
11:00-11:25	Regulation of human hematopoietic normal and leukemic stem cells by SCL/TAL1 and NOTCH	Francosie Pflumio (CEA-IRCM)
11:25-11:50	Neural stem and progenitor cells response to ionizing radiation	Francoise Boussin (CEA-IRCM)
11:50-13:20	Lunch break (90)
	Session 6: Radio-toxicology	Chair:Masashi Kusakabe(NIRS) Laure Sabatier (CEA)
13:20-13:45	Homologous recombination is involved in the response to low doses of tritium contamination, in mammalian cells	Bernard Lopez (CEA-IRCM)
13:45-14:10	Uranium-affine proteins : screening, characterization and perspectives	Eric Quéméneur (CEA-IBEB)
14:10-14:35	Uranium induced renal toxicity during immature stage: Uranium dynamics and distribution in kidney	Shino Takeda (NIRS)
14:35-14:50	Coffee Break (15)
14:50-15:15	Effects of ionizing radiation on bacterial community	Nobuyoshi Ishii (NIRS)
15:15-15:40	Deinococcus deserti: Radiation resistance and adaptation to harsh environmental conditions	Thierry Heulin (CEA-IBEB)
Discussion time for collaboration M15:40 - Mobility of researchers (postdoctoral level): identification of specific profiles and scientific topics; NIRS and CEA propositions. Group 1 "Stems cells" Group 2 "DNA damage / Repair and checkpoints" Group 3 "Radio-carcinogenesis, Low dose effects and Radio-toxicology"
abbr. CEA--------- Commissariat à l' Énergie Atomique IBEB-------- Institut de biologie environnementale et de biotechnologie IBITEC-S---- Institut de biologie et de technologies de Saclay IRCM-------- Institut de radiobiologie cellulaire et moleculaire NIRS-------- National institute of radiological sciences NIHS-------- National institute of health sciences